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Tohoku University Technology: Diagnostic Marker for Optic Nerve Disorders: T17-035

Identifying markers from samples of glaucoma model mice. Currently acquiring human clinical sample data.

A representative example of optic nerve disorders is glaucoma. Glaucoma has no subjective symptoms, so patients may not notice it as the condition progresses, potentially leading to blindness in the worst cases. Traditionally, the diagnosis of glaucoma has primarily involved fundus examinations, which are not easy methods and are not high-throughput diagnostic methods. The inventors conducted metabolome analysis using the retinas of glaucoma model mice (optic nerve crush mice) and identified several markers that change with the progression of glaucoma. The identified markers are expected to be utilized as markers for optic nerve disorders such as glaucoma. Currently, data is being collected from human clinical samples (such as blood). There are unpublished data (human blood sample data).

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